AZAD LAB for Synthetic Biology
Université de Sherbrooke, Faculté de Médecine et des Sciences de la Santé,
Département de microbiologie et d'infectiologie
Publications:
38. CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX, Jack T Whelan, Ragunath Singaravelu, Fuan Wang, Adrian Pelin, Levi A Tamming, Giuseppe Pugliese, Nikolas T Martin, Mathieu Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Jessie Duong, Carter Jones, Emily E. F. Brown, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Michael Huh, Matthew Y Tang, Zaid Taha, Elena Scut, Jean-Simon Diallo, Taha Azad, Brian D Lichty, Carolina S Ilkow and John Cameron Bell, Frontiers in Immunology, 2023.
37. Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection, Stephen Boulton, Joanna Poutou, Nikolas T Martin, Taha Azad, Ragunath Singaravelu, Mathieu JF Crupi, Taylor Jamieson, Xiaohong He, Ricardo Marius, Julia Petryk, Christiano Tanese de Souza, Bradley Austin, Zaid Taha, Jack Whelan, Sarwat T Khan, Adrian Pelin, Reza Rezaei, Abera Surendran, Sarah Tucker, Emily EF Brown, Jaahnavi Dave, Jean-Simon Diallo, Rebecca Auer, Jonathan B Angel, D William Cameron, Jean-Francois Cailhier, Réjean Lapointe, Kyle Potts, Douglas J Mahoney, John C Bell, Carolina S Ilkow, Molecular Therapy, 2022.
36. Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy, Marie-Eve Wedge, Victoria A Jennings, Mathieu JF Crupi, Joanna Poutou, Taylor Jamieson, Adrian Pelin, Giuseppe Pugliese, Christiano Tanese de Souza, Julia Petryk, Brian J Laight, Meaghan Boileau, Zaid Taha, Nouf Alluqmani, Hayley E McKay, Larissa Pikor, Sarwat Tahsin Khan, Taha Azad, Reza Rezaei, Bradley Austin, Xiaohong He, David Mansfield, Elaine Rose, Emily EF Brown, Natalie Crawford, Almohanad Alkayyal, Abera Surendran, Ragunath Singaravelu, Dominic G Roy, Gemma Migneco, Benjamin McSweeney, Mary Lynn Cottee, Egon J Jacobus, Brian A Keller, Takafumi N Yamaguchi, Paul C Boutros, Michele Geoffrion, Katey J Rayner, Avijit Chatterjee, Rebecca C Auer, Jean-Simon Diallo, Derrick Gibbings, Benjamin R tenOever, Alan Melcher, John C Bell, Carolina S Ilkow, Nature communications, 2022.
35. Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen, Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E Carter-Timofte, Naziia Kurmasheva, Line S Reinert, Andrew Chen, Mathieu JF Crupi, Stephen Boulton, Geneviève Laroche, Alexandra Phan, Reza Rezaei, Nouf Alluqmani, Anna Jirovec, Alexandra Acal, Emily EF Brown, Ragunath Singaravelu, Julia Petryk, Manja Idorn, Kyle G Potts, Hayley Todesco, Cini John, Douglas J Mahoney, Carolina S Ilkow, Patrick Giguère, Tommy Alain, Marceline Côté, Søren R Paludan, David Olagnier, John C Bell, Taha Azad, Jean-Simon Diallo, Molecular Therapy, 2022.
34. A computational approach to rapidly design peptides that detect SARS-CoV-2 surface protein S, Maryam Hajikarimlou, Mohsen Hooshyar, Mohamed Taha Moutaoufik, Khaled A Aly, Taha Azad, Sarah Takallou, Sasi Jagadeesan, Sadhna Phanse, Kamaledin B Said, Bahram Samanfar, John C Bell, Frank Dehne, Mohan Babu, Ashkan Golshani, NAR genomics and bioinformatics, 2022.
33. Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer, Mathieu JF Crupi, Zaid Taha, Thijs JA Janssen, Julia Petryk, Stephen Boulton, Nouf Alluqmani, Anna Jirovec, Omar Kassas, Sarwat T Khan, Sydney Vallati, Emily Lee, Ben Zhen Huang, Michael Huh, Larissa Pikor, Xiaohong He, Ricardo Marius, Bradley Austin, Jessie Duong, Adrian Pelin, Serge Neault, Taha Azad, Caroline J Breitbach, David F Stojdl, Michael F Burgess, Scott McComb, Rebecca Auer, Jean-Simon Diallo, Carolina S Ilkow, John Cameron Bell, Frontiers in Immunology, 2022.
32. Antiviral potential of the antimicrobial drug atovaquone against SARS-CoV-2 and emerging variants of concern, Madalina Elena Carter-Timofte, Rozanne Arulanandam, Naziia Kurmasheva, Kathy Fu, Geneviève Laroche, Zaid Taha, Demi van Der Horst, Lena Cassin, Renée M van der Sluis, Enrico Palermo, Daniele Di Carlo, David Jacobs, Glib Maznyi, Taha Azad, Ragunath Singaravelu, Fanghui Ren, Anne Louise Hansen, Manja Idorn, Christian K Holm, Martin R Jakobsen, Julien van Grevenynghe, John Hiscott, Søren R Paludan, John C Bell, Jean Seguin, Luc A Sabourin, Marceline Côté, Jean-Simon Diallo, Tommy Alain, David Olagnier, ACS infectious diseases, 2021.
31. Industrial applications of immobilized nano-biocatalysts, Mozhgan Razzaghi, Ahmad Homaei, Fabio Vianello, Taha Azad, Tanvi Sharma, Ashok Kumar Nadda, Roberto Stevanato, Muhammad Bilal, Hafiz Iqbal, Bioprocess and Biosystems Engineering, 2021.
30. Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter, Reza Rezaei, Abera Surendran, Ragunath Singaravelu, Taylor R Jamieson, Parisa Taklifi, Joanna Poutou, Taha Azad, Carolina S Ilkow, Journal of Visualized Experiments, 2021.
29. Luciferase-Based Biosensors in the Era of the COVID-19 Pandemic, Taha Azad, Helena J Janse van Rensburg, Jessica Morgan, Reza Rezaei, Mathieu JF Crupi, Rui Chen, Mina Ghahremani, Monire Jamalkhah, Nicole Forbes, Carolina Ilkow, John C Bell, ACS Nanoscience Au, 2021.
28. Synthetic peptides that antagonize the angiotensin-converting enzyme-2 (ACE-2) interaction with SARS-CoV-2 receptor binding spike protein, Afsaneh Sadremomtaz, Zayana M Al-Dahmani, Angel J Ruiz-Moreno, Alessandra Monti, Chao Wang, Taha Azad, John C Bell, Nunzianna Doti, Marco A Velasco-Velázquez, Debora de Jong, Jørgen de Jonge, Jolanda Smit, Alexander Dömling, Harry van Goor, Matthew R Groves, Journal of Medicinal Chemistry, 2021.
27. Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection, Taylor R Jamieson, Joanna Poutou, Ricardo Marius, Xiaohong He, Reza Rezaei, Taha Azad, Carolina S Ilkow, Journal of Visualized Experiments, 2021.
26. SARS-CoV-2 S1 NanoBiT: A nanoluciferase complementation-based biosensor to rapidly probe SARS-CoV-2 receptor recognition, Taha Azad, Ragunath Singaravelu, Emily EF Brown, Zaid Taha, Reza Rezaei, Rozanne Arulanandam, Stephen Boulton, Jean-Simon Diallo, Carolina S Ilkow, John C Bell, Biosensors and Bioelectronics, 2021.
25. A high-throughput NanoBiT-based serological assay detects SARS-CoV-2 seroconversion, Taha Azad, Reza Rezaei, Ragunath Singaravelu, Taylor R Jamieson, Mathieu JF Crupi, Abera Surendran, Joanna Poutou, Parisa Taklifi, Juthaporn Cowan, Donald William Cameron, Carolina S Ilkow, Nanomaterials, 2021.
24. Characterization of critical determinants of ACE2–SARS CoV-2 RBD interaction, Emily EF Brown, Reza Rezaei, Taylor R Jamieson, Jaahnavi Dave, Nikolas T Martin, Ragunath Singaravelu, Mathieu JF Crupi, Stephen Boulton, Sarah Tucker, Jessie Duong, Joanna Poutou, Adrian Pelin, Hamed Yasavoli-Sharahi, Zaid Taha, Rozanne Arulanandam, Abera Surendran, Mina Ghahremani, Bradley Austin, Chantal Matar, Jean-Simon Diallo, John C Bell, Carolina S Ilkow, Taha Azad, International journal of molecular sciences, 2021.
23. Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry, Taha Azad, Ragunath Singaravelu, Zaid Taha, Taylor R Jamieson, Stephen Boulton, Mathieu JF Crupi, Nikolas T Martin, Emily EF Brown, Joanna Poutou, Mina Ghahremani, Adrian Pelin, Kazem Nouri, Reza Rezaei, Christopher Boyd Marshall, Masahiro Enomoto, Rozanne Arulanandam, Nouf Alluqmani, Reuben Samson, Anne-Claude Gingras, D William Cameron, Peter A Greer, Carolina S Ilkow, Jean-Simon Diallo, John C Bell, Molecular Therapy, 2021.
22. Plant-based expression of SARS-CoV-2 antigen for use in an oral vaccine, Monique Power, Taha Azad, John C Bell, Allyson M MacLean, Journal of Food Science and Nutrition Research, 2021.
21. Rox8 promotes microRNA-dependent yki messenger RNA decay, Xiaowei Guo, Yihao Sun, Taha Azad, HJ Janse van Rensburg, Jingjing Luo, Shuai Yang, Peng Liu, Zhongwei Lv, Meixiao Zhan, Ligong Lu, Yingqun Zhou, Xianjue Ma, Xiaoping Zhang, Xiaolong Yang, Lei Xue, Proceedings of the National Academy of Sciences, 2020.
20. Implications for SARS-CoV-2 vaccine design: Fusion of spike glycoprotein transmembrane domain to receptor-binding domain induces trimerization, Taha Azad, Ragunath Singaravelu, Mathieu JF Crupi, Taylor Jamieson, Jaahnavi Dave, Emily EF Brown, Reza Rezaei, Zaid Taha, Stephen Boulton, Nikolas T Martin, Abera Surendran, Joanna Poutou, Mina Ghahremani, Kazem Nouri, Jack T Whelan, Jessie Duong, Sarah Tucker, Jean-Simon Diallo, John C Bell, Carolina S Ilkow, Membranes, 2020.
19. Hippo signaling pathway as a central mediator of receptors tyrosine kinases (RTKs) in tumorigenesis, Taha Azad, Reza Rezaei, Abera Surendran, Ragunath Singaravelu, Stephen Boulton, Jaahnavi Dave, John C Bell, Carolina S Ilkow, Cancers, 2020.
18. A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis, Taha Azad, Kazem Nouri, Helena J Janse van Rensburg, Sarah M Maritan, Liqing Wu, Yawei Hao, Tess Montminy, Jihang Yu, Prem Khanal, Lois M Mulligan, Xiaolong Yang, Oncogene, 2020.
17. A kinome‐wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion, Kazem Nouri, Taha Azad, Elizabeth Lightbody, Prem Khanal, Christopher J Nicol, Xiaolong Yang, The FASEB Journal, 2019.
16. Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors, Kazem Nouri, Taha Azad, Min Ling, Helena J Janse van Rensburg, Alexander Pipchuk, He Shen, Yawei Hao, Jianmin Zhang, Xiaolong Yang, Cancers, 2019.
15. Hippo Pathway Bioluminescent Biosensor, Xiaolong Yang, Taha Azad, Kazem Nouri, US Patent 16177691, 2019.
14. The role of YAP and TAZ in angiogenesis and vascular mimicry, Taha Azad, Mina Ghahremani, Xiaolong Yang, Cells, 2019.
13. TAZ enhances mammary cell proliferation in 3D culture through transcriptional regulation of IRS1, Helena J Janse van Rensburg, Dulcie Lai, Taha Azad, Yawei Hao, Xiaolong Yang, Cellular Signalling, 2018.
12. Monitoring Hippo signaling pathway activity using a luciferase-based large tumor suppressor (LATS) biosensor, Taha Azad, Kazem Nouri, Helena J Janse van Rensburg, Yawei Hao, Xiaolong Yang, Journal of Visualized Experiments, 2018.
11. PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling PathwaysYAP/TAZ Regulation by PIK3CB in Mammary Tumorigenesis, Yulei Zhao, Tess Montminy, Taha Azad, Elizabeth Lightbody, Yawei Hao, Sandip SenGupta, Eric Asselin, Christopher Nicol, Xiaolong Yang, Molecular Cancer Research, 2018.
10. The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1TAZ Regulates Cancer Immune Evasion through PD-L1, Helena J Janse van Rensburg, Taha Azad, Min Ling, Yawei Hao, Brooke Snetsinger, Prem Khanal, Lori M Minassian, Charles H Graham, Michael J Rauh, Xiaolong Yang, Cancer research, 2018.
9. A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis, T Azad, HJ Janse van Rensburg, ED Lightbody, B Neveu, A Champagne, A Ghaffari, VR Kay, Y Hao, H Shen, B Yeung, BA Croy, KL Guan, F Pouliot, J Zhang, CJB Nicol, X Yang, Nature communications, 2018.
8. Olfactory Epithelium as an Infinitive Source of Neural Stem Cells for Derivation of Inner Ear Hair Cells, Tahere Bahmani, Samira Gholami, Ali Mostafaie, Ebrahim Karimi, Zohreh Hoseinkhani, Taha Azad, Hamid Mahdizadeh, Kamran Mansouri, International Journal of Morphology, 2017.
7. Inhibition of mir-15a Gene Expression by Silibinin in MCF-7 Breast Cancer Cell Line, Seyede Elmira Yazdi Rouholamini, Nasrin Motamed, Elnaz Birjandian, Taha Azad, Kobra Omidfar, International Journal of Current Research and Academic Review, 2015.
6. Oscillation of apoptosome formation through assembly of truncated Apaf-1, Taha Azad, Amin Tashakor, Fereshteh Rahmati, Roohullah Hemmati, Saman Hosseinkhani, European journal of pharmacology, 2015.
5. Luciferin‐regenerating enzyme mediates firefly luciferase activation through direct effects of D‐cysteine on luciferase structure and activity, Roohullah Hemmati, Saman Hosseinkhani, Reza H Sajedi, Taha Azad, Amin Tashakor, Nuredin Bakhtiari, Farangis Ataei, Photochemistry and Photobiology, 2015.
4. Split-luciferase complementary assay: applications, recent developments, and future perspectives, Taha Azad, Amin Tashakor, Saman Hosseinkhani, Analytical and bioanalytical chemistry, 2014.
3. Apoptotic protease-activating factor 1 (Apaf-1) as a gene for spontaneous mutations in vitro, Taha Azad, Amin Tashakor, Mina Ghahremani, Roohullah Hemmati, Farangis Ataei, Saman Hosseinkhani, Progress in Biological Sciences, 2014.
2. Ornithine-induced increase of proline and polyamines contents in tobacco cells under salinity conditions, Mina Ghahremani, Faezeh Ghanati, Francoise Bernard, Taha Azad, Morteza Gholami, Masoumeh Safari, Australian Journal of Crop Science, 2014.
1. Effects of exogenous ornithine enantiomers on tobacco cells under salinity conditions, Mina Ghahremani, Faezeh Ghanati, Francoise Bernard, Morteza Gholami, Taha Azad, Progress in Biological Sciences, 2013.